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MGMT Gene Silencing and Benefit From Temozolomide in Glioblastoma NEJM 352:997-1003, 1036, Hegi,M.E., et al, 2005 See this aricle in Pubmed Article Abstract Patients with glioblastoma containing a methylated MGMT promotor benefited from temozolomide, whereas those who did not have a methylated MGMT promotor did not have such a benefit.

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